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Professor William Henry Colledge leads the Reproductive Physiology group at the University of Cambridge, focusing on transgenic mouse models of human disease to understand disease mechanisms and develop new treatment strategies. His research centers on the genetic factors influencing normal development and the complexities of gametogenesis. The group has made significant strides in reproductive physiology, particularly in revealing the functions of the c-mos proto-oncogene in oogenesis, demonstrating that female mice lacking this gene experience reduced fertility. Furthermore, they have identified critical roles for specific genes like cyclin A1 in spermatogenesis, noting that its absence can lead to severe fertility issues in male mice. Current investigations delve into the neuroendocrine factors necessary for maintaining mammalian fertility, especially the G-protein coupled receptor (GPR54) as a key regulator of the reproductive axis. Insights from this work have implications for understanding conditions like precocious puberty, idiopathic infertility, and the management of reproductive health in both humans and domestic animals.
Standard postgraduate requirements for Department of Politics and International Studies (POLIS) and related humanities departments.