Dr. William Dunphy

Biography

William G. Dunphy is the Grace C. Steele Professor of Biology at the California Institute of Technology. He completed his undergraduate degree at Harvard College in 1980 and earned his Ph.D. at Stanford University in 1985. Dunphy began his academic career as an Assistant Professor at Caltech from 1989 to 1995, was promoted to Associate Professor in 1995, and became a full Professor in 2001. His research primarily focuses on cell cycle checkpoints, DNA replication, and the preservation of genomic integrity. He studies the enzymatic networks that regulate the entry of cells into mitosis and has identified key regulatory mechanisms involving master kinases such as MPF and ATR, among others. His ongoing work aims to elucidate the molecular pathways associated with genomic stability, which is critical for understanding cancer and other health issues related to genomic deterioration.

Research Interests