Dr. William Sessa

Biography

William C. Sessa is the Alfred Gilman Professor Emeritus at the Department of Pharmacology, Yale School of Medicine. His work has defined crucial molecular aspects and physiological implications of endothelial nitric oxide synthase (eNOS) activation, contributing significantly to the understanding of how nitric oxide (NO) regulates angiogenesis, vascular permeability, and atherosclerosis. His research highlights include cloning eNOS during his post-doctoral work, identifying subcellular trafficking of eNOS, and understanding the mechanisms that regulate cardiac homeostasis through protein-protein interactions. In addition to his focus on eNOS, Dr. Sessa has expanded his research to explore the role of caveolae in plasma membrane signaling and the Akt pathway, which is essential for the regulation of angiogenic growth factors. He has trained numerous graduate students and mentored over 40 post-doctoral fellows, taking on leadership roles across various academic institutions.

Research Interests