Dr. Wolfgang Maret

Biography

Wolfgang Maret's research focuses on biochemical principles and the organic and inorganic chemistry of life. His laboratory investigates the inorganic biochemical aspects of metal ions that are nutritionally essential for human life, particularly manganese, iron, copper, and zinc. These metal ions are components of thousands of proteins that facilitate enzymatic catalysis and influence protein structure. The regulation of protein functions by transition metal ions plays a critical role in cellular metal ion homeostasis, requiring intricate interactions of multiple proteins involved in transport, sensing, and chaperoning. Maret studies the molecular mechanisms employed by metal-regulatory proteins, particularly those involving sulfur-ligand centered reactivity and the redox activity of zinc. His work aims to provide insights into how transition metal ion homeostasis controls pharmacological activities and the toxic actions of metal ions, potentially aiding the development of strategies to optimize human health and address various diseases. Currently, his research output includes articles examining the interactions of zinc with key signaling pathways and its implications for health and disease, contributing significantly to the field of metallomics and biochemistry.

Research Interests

Experience