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Dr. Xianxin Hua is a Professor in the Department of Cancer Biology at the Perelman School of Medicine, University of Pennsylvania. His research focuses on elucidating the molecular mechanisms by which Menin, a contextual tumor suppressor scaffold protein, interacts with various epigenetic regulators, thus regulating normal cellular functions and cancers. Dr. Hua's lab investigates the Menin pathway's regulation of pancreatic beta cells, neuroendocrine tumors (NETs), colorectal cancer (CRC), and a subset of acute myeloid leukemia (AML). His work has involved the development of the Sequential Tumor-selected Antibody antigen-Retrieval (STAR) platform that isolates NET and AML-selective nanobodies, and he is developing novel chimeric antigen receptor (CAR) T cells for the treatment of NETs and AML. His comprehensive research approaches employ protein cell engineering, synthetic biology, bioinformatics, gene editing, and immunotherapy to provide insights into Menin-mediated epigenetic regulation and pave the way for new immunotherapeutic strategies for AML and solid tumors.
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