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Xiaolei Su received his initial scientific training at Peking University and obtained his Ph.D. from Harvard University, focusing on Cell and Developmental Biology. He joined Ron Vale's Lab at UCSF as a postdoctoral fellow, where he revealed that phase separation of membrane-associated proteins promotes T cell activation. Su started his own research group at Yale in 2018, where his research focuses on membrane remodeling and receptor signaling in T cell and mast cell-mediated immune responses. His team combines biochemical reconstitution, live cell imaging, and animal models to understand the role of biomolecular condensation in regulating immune signaling. Su's work also involves investigating molecular pathways underlying CAR (Chimeric Antigen Receptor) activation and designing CARs with new signaling functions targeting various cancers. He addresses mechanisms of immunotherapy development and explores how mast cells can be repurposed for anti-tumor functions. Additionally, he examines transcellular migration of leukocytes and cancer cells through endothelial layers, focusing on the mechanisms involved in these processes.
Administered via the Graduate School of Arts and Sciences (GSAS). GRE General is optional for PhD.