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Xiaoli Tang is an Assistant Professor in the Department of Medicine at Brown University. Her current research focuses on HIV-1 latency reversal and elimination. With a significant transformation in the treatment of HIV infection from a death sentence to a controllable chronic disease, she is investigating the challenges posed by latent HIV-1 reservoirs—a major obstacle to curing HIV-1 infection. Her work involves the innovative 'Shock and Kill' strategy, which aims to reactivate these latent reservoirs and expose them to the immune system, thereby attempting to eliminate the virus. Dr. Tang has contributed to notable studies, such as engineering exosomal Tat to reactivate latent HIV-1 reservoirs in resting CD4+ T cells, which showed promise in her research published in JCI Insight. Her work encompasses combination therapies that integrate exosomal Tat with bispecific T-cell engaging molecules to enhance immune responses against HIV-1. Dr. Tang's rigorous approach employs both ex vivo and in vivo experiments to test these combinations for reducing or eliminating HIV-1 reservoirs.
Warren Alpert Medical School of Brown University • Providence, RI
Conducted research in infectious diseases.
Warren Alpert Medical School of Brown University • Providence, RI
Focused on surgical research at Rhode Island Hospital.
Warren Alpert Medical School of Brown University • Providence, RI
Investigated liver research at Rhode Island Hospital.
Department: Department of Economics