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Xiaoping Zhong is a Professor in the Department of Pediatrics and the Department of Integrative Immunobiology at Duke University, where he is also a member of the Duke Cancer Institute. His research focuses on understanding how receptor signaling mediates the regulation of immune cell development and function, particularly in the context of pathogenesis and treatment of autoimmune diseases and allergies. He is currently investigating the roles of diacylglycerol kinases (DGKs) in the immune system. DGKs, a family of ten enzymes, catalyze the conversion of diacylglycerol (DAG) to phosphatidic acid (PA), both of which serve as significant signaling molecules in numerous receptor pathways. His research has revealed critical roles for the DGKα and ζ isoforms in T cell development, activation, and anergy, as well as their impact on mast cell function and innate immune responses. His ongoing research interests include T cell maturation mechanisms, NKT cell development, thymic epithelial cell function, and the pathogenesis of autoimmune hepatitis and peanut allergy.
Duke University • Durham, NC
Holds a professorship position in Pediatrics and Integrative Immunobiology.
Duke University • Durham, NC
Served as an Associate Professor in Pediatrics and Immunology.
Duke University • Durham, NC
Worked as an Assistant Professor in Pediatrics and Immunology.
Duke University • Durham, NC
Taught as a temporary instructor in Pediatrics.
Department of Biomedical Engineering (MS program)