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Dr. Xiaoying Shen is an Associate Professor in the Department of Surgery at Duke University Medical Center and a member of the Duke Human Vaccine Institute, where she serves as Deputy Director of the Laboratory for HIV COVID-19 Vaccine Research and Development. Her research primarily focuses on the humoral immune response to virus infections and vaccinations, specifically the breadth and specificity of binding antibody responses to HIV over the past decade. Dr. Shen has developed analytical tools such as peptide microarray assays to map HIV-1 cross-subtype epitopes targeted by antibody responses in human samples and animal models. Her team employs multiplex binding assays to evaluate antibody responses in clinical trials and studies involving non-human primates. Following the onset of the COVID-19 pandemic, Dr. Shen's research expanded to include the investigation of SARS-CoV-2 antibody responses. In 2021, she became the Deputy Director of the laboratory, which successfully established a lentivirus-based pseudovirus assay for SARS-CoV-2 neutralization now FDA-approved, and is actively assessing neutralizing antibody responses in multiple phase 3 vaccine trials.
Duke University Medical Center • Durham, NC
Active in the Department of Surgery and the Duke Human Vaccine Institute, focusing on immune responses to HIV and COVID-19.
Duke University Medical Center • Durham, NC
Previously held a position as an Assistant Professor in Surgery and Medicine.
Department of Biomedical Engineering (MS program)