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Xin He is a Professor in the Department of Human Genetics at the University of Chicago. His research focuses on utilizing computational approaches to study the genetics of human diseases. He primarily develops novel tools for mapping risk genes associated with complex diseases through genome-wide association studies (GWAS) and sequencing studies. His methodology is distinguished by close collaboration with experimental biologists, employing an integrated strategy that combines multiple genomic datasets, transcriptome data, epigenetic data, and biological networks. This integrated approach enhances analytical power and elucidates mechanisms linking genetic variations to phenotypes. He has specific interests in regulatory genomics, particularly in understanding how cis-regulatory sequences influence gene expression patterns in response to cellular environments, and the evolutionary implications of variations in these regulatory sequences. Through his investigations, he aims to advance the interpretation of variations in non-coding DNA sequences relevant to human genetics.
Department of Philosophy