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Xue Gao is an Associate Professor in the Department of Chemical and Biomolecular Engineering at the University of Pennsylvania. His research focuses on genome editing, synthetic biology, enzymology, and protein engineering. His work has contributed to significant advancements in the field, including the development of Evolved Cas9 variants that demonstrate broad PAM compatibility and high DNA specificity. He has published extensively in top-tier journals and has made substantial contributions to the understanding of CRISPR-Cas biochemistry. Dr. Gao's research employs innovative techniques for the efficient delivery of genome-editing proteins, leveraging bioreducible lipid nanoparticles. He has also explored the treatment of autosomal dominant hearing loss through the delivery of genome editing agents. In addition to his engineering contributions, his work on biosynthesis pathways in fungi has shed light on the complexities of peptide production, further driving advancements in the fields of microbiology and biochemistry. Xue Gao leads a lab that focuses on applying these interdisciplinary approaches to solve real-world problems in medicine and biotechnology.
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