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Xuelin Lou is a Professor at the UW Comprehensive Diabetes Center at the University of Wisconsin–Madison. With a medical degree and a doctorate, his research primarily focuses on major types of vesicles, including large dense-core vesicles (LDCV) and small synaptic vesicles (SV), utilizing neuron and β-cell models. His primary goal is to elucidate the molecular mechanisms underlying insulin granule trafficking in diabetes. Dr. Lou's group has established cutting-edge tools for research, such as super-resolution imaging, subcellular optogenetics, single-granule fusion/fission assays, and membrane capacitance recordings, along with novel mouse models. Recent progress from his research highlights the crucial role of dynamin and cortical actin in insulin exocytosis, leading to discoveries that motivate further investigation into the central genes governing cortical actin polymerization.
Department: Department of Computer Sciences