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For the past 18 years, Yan Burelle has developed a research program focused on integrative mitochondrial biology. His laboratory has built strong expertise in analyzing various facets of mitochondria, combining detailed mechanistic studies with functional repercussions analysis of isolated organelles, permeabilized intact cells, mouse models of disease, and fibroblasts from muscle biopsies. His research includes bioenergetics and metabolism, with a focus on processes such as reactive oxygen species (ROS) metabolism, permeability transition pore opening, mitochondrial quality control mechanisms, and mitophagy. Burelle's work successfully merges cutting-edge imaging molecular techniques with omics functional analyses to gain valuable insights into the basic biology of organelles and their roles in the pathophysiology of genetic and acquired diseases. Professor Burelle is currently accepting new students for thesis supervision.
Department of History