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Yanxiang Guo is an Associate Professor at the Rutgers Cancer Institute and the Department of Medicine at Robert Wood Johnson Medical School, Rutgers, State University of New Jersey. His research predominantly focuses on cancer metabolism, particularly the role of autophagy in modulating Ras-driven cancer metabolism and its impact on Kras-driven lung tumor growth and metastasis. Guo's lab is investigating the unique metabolic characteristics of cancer cells compared to normal cells, underscoring the potential of targeting cancer metabolism as a therapeutic strategy. His studies have demonstrated that autophagy is essential for maintaining functional mitochondria that support Kras-driven non-small cell lung cancer (NSCLC) and have implications for therapeutic strategies targeting autophagy and mitochondrial function. Additionally, his research looks into how autophagy contributes to NSCLC metastasis, aiming to uncover novel drug targets. Guo employs a combination of genetically engineered mouse models and advanced metabolomic and lipidomic analyses to achieve these research objectives.