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The Chang Lab at the University of Pennsylvania focuses on structural biology to understand the basis of various biological processes from a structural perspective. The lab employs cryo-electron tomography (cryo-ET) as a powerful imaging technique that allows researchers to study the structure and mechanism of macromolecular machines directly within cells. By utilizing cryo-ET, the lab can reveal native conformations and assemblies of these machines, along with their functions, distributions, orientations, and interactions with cellular components. This approach provides a unique opportunity to uncover structural mechanisms that drive complex cellular activities and host-pathogen interactions. The lab's research encompasses several areas, including cellular structural biology, microbiology, and structural parasitology, with a specific focus on the discovery of the rhoptry secretory apparatus in malaria parasites. The Chang Lab is also interested in the development of cryo-ET methods, super-resolution imaging, and the implications of these techniques in addressing fundamental biological questions.
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