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Yitzhak Tor's laboratory focuses on the development of small molecules that interact with RNA, which plays a central role in numerous biological processes. His long-term goal is to understand RNA-ligand interactions in order to develop molecules that can specifically interfere with essential RNA-RNA and RNA-protein complexes. This work involves analyzing the structural and functional features of various families of RNA-binding molecules through synthetic chemistry, biochemical assays, and biophysical tools. Dr. Tor's research also explores the design and synthesis of novel luminescent molecules that can be used to create emissive probes based on organic metal-containing chromophores, with a particular focus on fluorescent analogs of biologically important nucleotides. In addition, he investigates the mechanisms through which delivery systems based on guanidinoglycosides can facilitate the uptake of large, bioactive molecules into living cells, which has significant implications for drug delivery applications. Through his outreach activities, Dr. Tor actively mentors underrepresented students in science, providing them with essential research experiences and supporting their professional development in the field.
University of Chicago • Chicago, IL
California Institute of Technology • Pasadena, CA
Administered by the Scripps Institution of Oceanography. Curricular groups include Climate-Ocean-Atmosphere (COAP), Geosciences (GEO), and Ocean Biosciences (OBP).