Dr. Yiyun Huang

Biography

Dr. Yiyun Huang's research focuses on the development of new and improved Positron Emission Tomography (PET) radioligands. This process involves interplays of chemistry, biology, pharmacology, and pharmacokinetics, requiring a thorough understanding of several scientific disciplines. Over the years, Dr. Huang has contributed to the development of PET radioligands for various neurotransmitter systems, including dopamine, serotonin, glutamate, and acetylcholine receptors and transporters in the brain. The development process involves several key stages: designing and synthesizing candidate ligands, conducting in vitro pharmacological experiments to assess binding affinities and selectivity, designing and executing biological pharmacological experiments in live animals to evaluate pharmacokinetics, binding selectivity, metabolism, clearance, and dosimetry. Clinical trials are essential for determining the suitability of these ligands for human applications. Current research interests also include ligands targeting central nervous system neurotransmission systems, underscoring the importance of PET radioligand development in advancing PET imaging techniques.

Research Interests