Dr. Yong Xiong

Biography

Yong Xiong's research focuses on structural biochemical studies of viral suppression, host antiviral factors, and viral immune evasion. He investigates cellular DNA repair pathways, employing techniques such as X-ray crystallography, cryo-electron microscopy, biochemistry, molecular biology, and computational biology. His work aims to uncover detailed mechanisms of SARS-CoV-2’s entry into cells and the immune responses initiated by the host. Specific research topics include the reprogramming of cellular translation by Nonstructural Protein 1 (Nsp1) of SARS-CoV-2, and the strategies viruses use to hijack host protein degradation and membrane trafficking pathways. He also explores the interactions between HIV and host cell proteins, specifically focusing on the role of capsid proteins and innate immune responses. His extensive research output highlights his contributions to the understanding of virology and biochemistry.

Research Interests