Dr. Yoshikazu Takada

Biography

Yoshikazu Takada is a distinguished professor in the Department of Biochemistry and Molecular Medicine at the University of California, Davis. He has made significant contributions to the field of integrin research, particularly in the identification and characterization of α1 integrins (VLA proteins) since the 1980s. His work includes cloning the α2, α3, and α4 subunits and identifying their respective ligands such as collagen and laminin. Profoundly engaged in structure-function studies, Takada has employed site-directed mutagenesis to explore putative ligand-binding sites of integrins, achieving results that align with the crystal structure of the integrin αvβ3-RGD complex. Currently, Takada's research focuses on the crosstalk between integrins and growth factors, having discovered direct interactions between integrins and FGF1, which are crucial for FGF signaling. He also identified that IGF-1 directly binds to integrins, indicating a significant role in IGF/IGF1R signaling pathways. His current research model suggests that integrins interact with the extracellular matrix (ECM) and growth factors, and that these signals converge to induce intracellular responses. His extensive publication record reflects his commitment to advancing our understanding of integrin function in cellular signaling and its implications for cancer and other diseases.

Research Interests