Dr. Yuan Tsong Chen

Biography

Yuan-Tsong Chen is a Professor Emeritus in the Department of Pediatrics at Duke University. His research interests lie in translational medicine, particularly in the field of genomic medicine. His current projects involve identifying novel genes and targets associated with human diseases, including susceptibility genes for common multifactorial diseases and adverse drug reactions. Dr. Chen utilizes a combination of genetic epidemiology, mouse ENU mutagenesis, and bioinformatics proteomics approaches for his research. He has made significant findings such as the identification of genetic markers for drug-induced Stevens-Johnson syndrome. He is engaged in prospective studies to assess the utilization of these markers to prevent adverse drug reactions. Additionally, Dr. Chen explores the molecular mechanisms associated with Stevens-Johnson syndrome and is investigating the role of novel glucose transporters in diabetes mellitus. His research includes enzyme gene therapy targeting mechanisms for Pompe disease, which is a severe genetic disorder affecting muscle function. Over his career, Chen has contributed to various grants from the National Institutes of Health for research on genetic mechanisms and diseases, and has held multiple academic positions, advancing significantly in the fields of molecular genetics and pediatrics.

Research Interests

Experience