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At the University of Chicago, Yun Fang leads an interdisciplinary research program that integrates vascular biology, functional genomics, bioengineering, and nanotechnology to define multilayered molecular mechanisms underlying gene regulatory programs that are dynamically controlled in health and disease. His laboratory investigates how mechanical and biochemical cues converge to regulate gene activity through the coordinated actions of transcription factors, the non-coding genome, epigenetic modifications, and intracellular signaling pathways, thus driving the pathogenesis of cardiovascular, fibrotic, and metabolic diseases. Additionally, Dr. Fang's team has developed an extensive portfolio of proprietary nanomaterials engineered for precise, cell- and tissue-specific delivery of therapeutic agents, such as nucleic acids and small molecules. These nanomedicine platforms are designed to selectively target diseased vascular stromal cells, enabling spatiotemporal modulation of dysregulated gene networks while minimizing off-target effects and systemic toxicity. By tightly coupling mechanistic discovery with therapeutic innovation, his program establishes a robust translational pipeline that bridges fundamental insights in mechanobiology and gene regulation with the development of next-generation targeted therapies for complex human diseases.
Department of Philosophy