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Yuqing Feng is an Assistant Professor in the Department of Biology at York University. His research focuses on the mechanisms by which antibodies play a crucial role in the immune system's response to pathogens. He investigates the genetic mechanisms that diversify the antibody repertoire, which allows for the production of a vast variety of antibodies capable of recognizing numerous antigens encountered over a lifetime. By studying B cell development, particularly V(D)J recombination in bone marrow, and the subsequent processes activated upon cognate antigen encounter, such as somatic hypermutation (SHM) and class switch recombination (CSR), Professor Feng aims to elucidate the complex pathways of antibody production. His work utilizes a range of biochemical, molecular, and genetic tools, including cell line and mouse models, to explore the interaction between base excision repair (BER) and mismatch repair (MMR) pathways in antibody diversification. Additionally, he examines the implications of DNA repair mechanisms on off-target AID deamination and their potential link to lymphomagenesis.
Department of Liberal Arts & Professional Studies graduate programs generally follow the Faculty of Graduate Studies (FGS) B+ minimum requirement.