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Zamaneh Kassiri is a professor in the Department of Physiology at the University of Alberta. Her research primarily focuses on the extracellular matrix (ECM) interactions with resident cells in the context of cardiac and vascular pathologies. The lab investigates the physiological turnover of ECM mediated by matrix metalloproteinases (MMPs), which degrade existing proteins and replace them with new ones, while also controlling the inhibitory functions of tissue inhibitors of metalloproteinases (TIMPs). TIMPs, a family of four members, inhibit multiple MMPs and regulate various cellular events, including the activity of ADAMs and ADAM-TSs. The lab aims to explore novel aspects of ECM functions in cardiovascular diseases, particularly the roles of non-fibrillar ECM proteins and non-MMP proteases. Methods employed include genetically modified animal models and human tissue analysis, allowing for comprehensive investigations of molecular mechanisms governing cardiovascular health.
Department: Mechanical Engineering and Engineering Management