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Zhaolan Zhou is a Professor in the Department of Genetics at the University of Pennsylvania School of Medicine. He has a research focus on the genetic and epigenetic mechanisms underlying neurodevelopmental disorders. His lab employs a combination of genomic technologies and cellular physiology to explore crucial questions related to gene function in brain development. Specifically, Dr. Zhou investigates the role of epigenetic regulation in diseases such as Rett syndrome, CDKL5 deficiency disorder, autism spectrum disorder, and major depressive disorder. His research aims to unravel how disruptions in epigenetic pathways can contribute to the pathogenesis of neuropsychiatric disorders. By utilizing genetically modified mouse models and human induced pluripotent stem cell models, Dr. Zhou's laboratory seeks to translate their findings into therapeutic interventions that could improve the quality of life for affected individuals. His work is pioneering in identifying molecular bases for stress vulnerability and studying pathogenic insights into X-linked disorders.
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