Dr. Ziad Mallat

Biography

Professor Ziad Mallat is a prominent researcher affiliated with the Cambridge Immunology Network at the University of Cambridge. His work focuses on the innate and adaptive immune responses that are involved in the initiation and progression of atherosclerosis and abdominal aortic aneurysm (AAA). His research highlights the therapeutic strategies aimed at targeting immune responses to manage atherosclerosis and AAA, especially as current medical therapies approved for treatment of AAA have limitations. Mallat has shown that specific subpopulations of regulatory T (Treg) cells can significantly inhibit the development of atherosclerotic lesions and associated inflammation. He hypothesizes that Treg cells, along with B cell type regulatory populations, play a broader role in controlling vascular inflammation that impacts the development and progression of atherosclerosis and AAA. His research aims to investigate the mechanisms behind the recruitment of T and B cell subsets to injured vessel walls and to explore pathways that modulate vascular inflammation. Additionally, he seeks to develop novel immuno-modulatory vaccination-based strategies to promote protective immune responses against these conditions.

Research Interests