Dr. Hydar Ali

Biography

Hydar Ali is a Professor and the Associate Dean for Faculty Development and Mentorship at Penn Dental Medicine. His research focuses on mast cells and their roles in host defense and chronic inflammatory diseases. Mast cells are granulated cells derived from hematopoietic lineage, predominantly found close to blood vessels in areas exposed to the external environment, including the skin, oral, gastrointestinal mucosa, and the respiratory tract. They contribute to vascular homeostasis, innate and adaptive immunity, and wound healing. Mast cells are critically involved in various allergic and inflammatory diseases such as anaphylaxis, food allergies, rhinitis, and asthma. His lab is particularly interested in the newly discovered G protein coupled receptor MRGPRX2, which has high affinity for the IgE receptor (Fc-epsilonRI) and participates in the immune response. His research utilizes cellular and molecular imaging approaches, both in vitro and in vivo, to study the mechanisms regulating MRGPRX2 and Fc-epsilonRI signaling. He has authored numerous publications and has been involved in various professional roles, including being an Associate Editor for the Journal of Immunology and serving on the American Heart Association Study Section.

Research Interests

Experience