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Matthew R. Hayes is an Associate Professor at the University of Pennsylvania, focusing on the identification and characterization of neural signaling pathways that control food intake and body weight regulation. His overarching goal is to develop effective treatments for obesity and its associated co-morbidities. His research examines various mechanisms—behavioral, intracellular, neuronal, and endocrine—that govern energy balance processes that are often dysregulated in obesity. Hayes' lab particularly emphasizes the role of neuropeptide glucagon-like peptide-1 (GLP-1) in regulating energy balance and its actions in both the periphery via the vagus nerve and within the central nervous system (CNS). Recent publications highlight potential GLP-1 receptor agonists as pharmacological treatments for obesity, emphasizing the need for a deeper understanding of the behavioral, neuronal, and physiological mechanisms of both peripheral and central GLP-1 systems in controlling food intake and body weight regulation.
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