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Paul Caton is a Reader at King's College London, focusing on Diabetes Nutrition. His research interests involve determining the molecular mechanisms underlying insulin resistance, beta-cell failure in Type 2 Diabetes (T2D), and the impact of dietary polyphenols on metabolic health. He investigates how adverse intrauterine environments, particularly maternal low-protein high-fat diets, affect the metabolic health of offspring. His work includes a systematic review on the molecular mechanisms linking Type 2 Diabetes Mellitus with late-onset Alzheimer's Disease. Notable contributions include studies on NAMPT activators, examining their action modes and their role as non-pyridyl class activators that could impact diabetes treatment. Additionally, he researches the effects of biomolecules such as carnosine on beta-cell function and the role of early-life nutrition in epigenetic modifications. His investigations also explore how psoriatic skin inflammation can induce a pre-diabetic phenotype and the overall functional changes in pancreatic beta cells due to high levels of eNAMPT. Caton is dedicated to advancing the understanding of islet dysfunction and identifying novel therapeutic targets to improve treatment strategies for Type 2 Diabetes and gestational diabetes, as well as enhancing islet transplantation therapies for Type 1 Diabetes.
King's College London • London, ENG
Conducting research in diabetes nutrition and teaching at various levels.
Requirements are consistent across King's Business School and Social Science & Public Policy departments for standard Master's entries.