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The research laboratory of Sheena Josselyn is dedicated to understanding the neural basis of cognitive function and dysfunction. Her work aims to unravel the molecular and cellular circuit processes that underlie learning and memory through a multidisciplinary approach using transgenic mice, gene deletion (knockout) mutants, 'knock' mutants carrying specific point mutations, biochemistry, pharmacology, and neuroanatomical lesions, in addition to detailed behavioral analysis. A guiding rationale of her work is that finding long-term memory (LTM) involves structural re-modeling of synaptic connections, which consequently requires gene expression and de novo protein synthesis. Her lab focuses on transcription factors that regulate the protein synthesis necessary for LTM formation. The broad theme of her research examines the pathogenesis of human cognitive disorders. By linking basic research findings with the theme of cognitive dysfunction in humans, she hopes to develop new therapeutic targets and treatment strategies. Her research program identifies disruptions in intracellular pathways linked to transcription factors that contribute to human cognitive impairments, positioning these factors as potential therapeutic targets for treatment of disorders.
Department of Sociology