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Professor Wilfred Jefferies earned his Doctor of Philosophy from the University of Oxford, focusing on Molecular Immunology Pathology. His significant contributions include discoveries related to glycoproteins on activated lymphocytes and the identification of the OX40 co-stimulatory immune checkpoint molecule. He has extensively studied the transferrin receptors at the Blood-Brain Barrier and their associated diseases. Dr. Jefferies has created the p97/melanotransferrin ‘Trojan Horse’ to deliver therapeutics for brain tumors. His research encompasses understanding mechanisms of immune subversion by viruses and tumors, delineating the epigenetic regulation of antigen processing in cancer cells. He has discovered the CD74-dependent Major Histocompatibility Complex-I recycling pathways critical for initiating immune responses. His current focus includes tumor immunology and cancer immunotherapy, particularly the restoration of the immune system’s ability to recognize tumors that evade detection. Dr. Jefferies leads initiatives on using IL-33 as a biomarker for prostate cancer prognosis. With over 100 publications and 60 patents, he has mentored numerous graduate students and postdoctoral fellows, creating foundations for several University spin-out companies.
Offers course-only and thesis routes. Focus areas include philosophy of science, mind, ethics, and Asian philosophy.